Regulation of Intracellular Signaling via Cellular Morphology

Meghan Driscoll , University of Texas Southwestern Medical Center, US online5:00 - 6:00 pm

Signaling is governed not only by the expression levels of molecules, but by their localization via mechanisms as diverse as compartmentalization in organelles, phase separation, and directed transport by motor proteins. Cell morphology likely also modulates the localization of signaling molecules, and recent advances in high-resolution light-sheet microscopy now allow imaging at the spatiotemporal resolution needed to capture the many undulations and quick dynamics of the 3D cell surface. However, these
microscopes generate large datasets with detailed 3D movies that require dedicated computational pipelines. In this seminar, I will introduce u-shape3D, a computer graphics and machine-learning pipeline to probe molecular mechanisms underlying 3D cell morphogenesis. U-shape3D includes a generic  morphological motif detector that automatically finds lamellipodia, filopodia, blebs and other motifs.

***Due to the current pandemic this colloquium will be conducted online. We invite you to join and spread the news. In case you wish to participate, please send an email up front to moldenha[at] to receive the zoom invitation link***